发明名称 |
SUBSTITUTED 3 - (THIAZOLE - 4 - CARBONYL) - OR 3 - (THIAZOLE - 2 - CARBONYL) AMINOPROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS |
摘要 |
<p>The present invention relates to compounds of the formulae (Ia) and (Ib), wherein G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae la and lb, their use and pharmaceutical compositions comprising them.</p> |
申请公布号 |
WO2013014205(A1) |
申请公布日期 |
2013.01.31 |
申请号 |
WO2012EP64629 |
申请日期 |
2012.07.25 |
申请人 |
SANOFI;RUF, SVEN;PERNERSTORFER, JOSEF;SADOWSKI, THORSTEN;HORSTICK, GEORG;SCHREUDER, HERMAN;BUNING, CHRISTIAN;WIRTH, KLAUS |
发明人 |
RUF, SVEN;PERNERSTORFER, JOSEF;SADOWSKI, THORSTEN;HORSTICK, GEORG;SCHREUDER, HERMAN;BUNING, CHRISTIAN;WIRTH, KLAUS |
分类号 |
C07D277/54;A61K31/426;A61K31/427;A61P9/00;A61P9/10;A61P9/12;A61P11/00;A61P13/00;C07D417/04 |
主分类号 |
C07D277/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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