发明名称 |
TREATMENT OF AUTOIMMUNE INFLAMMATION USING MIR-155 |
摘要 |
<p>The present disclosure relates to the finding that microRNA-155 plays a role in the development and activity of CD4+ T cells. CD4+ T cell development and function, particularly TH17 and TH1 T cell development, can be modulated by delivery of microRNA-155 (miR-155) or antisense miR-155 to target CD4+ cells or precursor cells. In some embodiments, antisense miR-155 is used to reduce tissue specific autoimmune inflalmmation and to treat autoimmune disease. In addition, miR155 and antisense miR-155 can be used to modulate expression of cytokines from dendritic cells.</p> |
申请公布号 |
WO2012037043(A9) |
申请公布日期 |
2013.01.31 |
申请号 |
WO2011US51265 |
申请日期 |
2011.09.12 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;BALTIMORE, DAVID;O'CONNELL, RYAN, M.;KAHN, DANIEL |
发明人 |
BALTIMORE, DAVID;O'CONNELL, RYAN, M.;KAHN, DANIEL |
分类号 |
A61K48/00;A61K38/16;A61K38/17;A61P19/02;A61P29/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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