It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products.
申请公布号
WO2013014191(A1)
申请公布日期
2013.01.31
申请号
WO2012EP64607
申请日期
2012.07.25
申请人
CHEMO IBERICA, S. A.;CARCONE, LUCA;MAGRONE, DOMENICO;BARRECA, GIUSEPPE;RASPARINI, MARCELLO;LI MING, HUAN
