| 摘要 |
A compound having the formula <IMAGE> wherein R1 is hydrogen, NH2 or C1-6-alkyl which may be branched; X is O, S, NCN; Y is O, S; R4, R5, R6 and R7 independently of each other are hydrogen, halogen, CF3, NO2, NH2, OH, C1-6-alkoxy, C(=O)-phenyl or SO2NRIRII wherein RI and RII independently are hydrogen or C1-6-alkyl; R11 is hydrogen, halogen, NO2 or SO2NR'R'' wherein R' and R'' independently are hydrogen or C1-6-alkyl; R13 is hydrogen, halogen, phenyl, CF3, NO2; R12 is hydrogen or together with R13 forms a C4-7-carbocyclic ring which may be aromatic or partially saturated; R14 is hydrogen or together with R13 forms a C4-7-carbocyclic ring which may be aromatic or partially saturated; pharmaceutical compositions thereof, and a method of treating a disease in a mammal, including a human, responsive to opening of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound as first above indicated, are disclosed.
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