| 摘要 |
A method for identifying a probable transmembrane domain in a polypeptide composed of n amino acid residues comprising providing the amino acid sequence, generating a vector Hi (where i = 1-n) of amino acid trait scores related to the likelihood of each corresponding amino acid being within a cell membrane, generating a vector Mi (where i = 1-n) of membrane associated scores from H each score being related to the likelihood of a corresponding amino acid and its neighbours being part of a transmembrane region, generating a vector Ti of transition associated scores from vector H each score being related to the likelihood of a corresponding amino acid and its neighbours being associated with a region of a polypeptide being a transition between a transmembrane and non transmembrane region and generating a vector Pi of probable transmembrane scores from vectors M and T using a combining algorithm each such score being located within a transmembrane region.
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