发明名称 |
Pharmaceutical compositions with improved dissolution |
摘要 |
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
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申请公布号 |
US8362062(B2) |
申请公布日期 |
2013.01.29 |
申请号 |
US20050541216 |
申请日期 |
2005.06.29 |
申请人 |
MCNEIL-PPC, INC.;TAWA MARK;REMENAR JULIUS;PETERSON MATTHEW L.;ALMARSSON OERN;GUZMAN HECTOR;CHEN HONGMING;OLIVEIRA MARK |
发明人 |
TAWA MARK;REMENAR JULIUS;PETERSON MATTHEW L.;ALMARSSON OERN;GUZMAN HECTOR;CHEN HONGMING;OLIVEIRA MARK |
分类号 |
A01N43/56;A61K9/14;A61K9/16;A61K9/64;A61K31/18;A61K31/365;A61K31/415;A61K31/635;A61K47/10;A61K47/32;C07B63/00;G01N21/27;G01N25/08;G01N25/12;G01N33/15 |
主分类号 |
A01N43/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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