发明名称 |
Characterization of N-glycans using exoglycosidases |
摘要 |
The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.
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申请公布号 |
US8361705(B2) |
申请公布日期 |
2013.01.29 |
申请号 |
US20080595925 |
申请日期 |
2008.04.15 |
申请人 |
MOMENTA PHARMACEUTICALS, INC.;PARSONS IAN CHRISTOPHER;BULIK DOROTA A.;BOSQUES CARLOS J.;THIRUNEELAKANTAPILLAI LAKSHMANAN;COLLINS BRIAN EDWARD |
发明人 |
PARSONS IAN CHRISTOPHER;BULIK DOROTA A.;BOSQUES CARLOS J.;THIRUNEELAKANTAPILLAI LAKSHMANAN;COLLINS BRIAN EDWARD |
分类号 |
C12Q1/00 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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