DEVICE AND METHOD FOR MEASURING SOLUBILITY AND FOR PERFORMING TITRATION STUDIES OF SUBMILLILITER QUANTITIES

摘要

Described is a device and method for facilitating the determination of the solubility and dissolution properties of chemical compounds in various solvents. The device uses submilliliter quantities of a solvent and correspondingly small amounts of the chemical compound. The device enables solubility measurements to be made on small amounts of chemical compounds, and enables multiple sampling for generating dissolution profiles. The device includes a housing having first chamber in fluid communication with a second chamber. A pump is provided to force alternatingly the solvent from one chamber to another. A filter located between, and in fluid communication with, the first and second chambers allow flow of a solution of the solvent and the chemical compound between the chambers, and the filter prevents the passage of undissolved compound. The device may also be used for titration studies of submilliliter quantities of solutions or suspensions.