EXTENDED SOLUBLE PH20 POLYPEPTIDES AND USES THEREOF

摘要

593641 Provided are soluble fragments of PH20 hyaluronidase peptides, which can be used for treating diseases involving an excess of glycosaminoglycans and for treating tumours, cardiovascular and pulmonary diseases. In cancer the peptide works by increasing chemotherapeutic agents into solid tumours. The peptides can in general increase the bioavailability of drugs and other therapeutic agents.