发明名称 |
Process for preparing dendritic cells, cells thus produced and containers for carrying out this process |
摘要 |
PCT No. PCT/DE95/00512 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 11, 1995 PCT Pub. No. WO95/28479 PCT Pub. Date Oct. 26, 1995Dendritic cells are of interest therapeutically as antigen-presenting cells. A process is disclosed in which peripheral blood cells are first isolated and the CD 34 antigen-expressing blood progenitor cells which they contain are then enriched. These enriched cells are expanded ex-vivo using a combination of haematopoietic growth factors and cytokines. Over a period of 10-20 days, they give rise, in particular to dendritic cells which, where appropriate, can be purified still further. These cells are functionally active with regard to the ability to present antigen.
|
申请公布号 |
US5866115(A) |
申请公布日期 |
1999.02.02 |
申请号 |
US19960727495 |
申请日期 |
1996.10.11 |
申请人 |
KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITAT FREIBURG |
发明人 |
KANZ, LOTHAR;BRUGGER, WOLFRAM;HENSCHLER, REINHARD;KOEHLER, GABRIELE;SCHAEFER, HANS-ECKART;LINDEMANN, ALBRECHT;MERTELSMANN, ROLAND;MACKENSEN, ANDREAS;FISCH, PAUL;HERBST, BIRGIT |
分类号 |
C12M1/00;A61K35/14;A61K38/00;A61K38/16;A61K38/22;A61P37/04;C12N5/0784;(IPC1-7):A61K35/00;A61K35/10;C12N15/85 |
主分类号 |
C12M1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|