发明名称 |
Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Metabolic Disorders |
摘要 |
The invention provides methods and compositions for selectively promoting anti-metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
|
申请公布号 |
US2013019326(A1) |
申请公布日期 |
2013.01.17 |
申请号 |
US201113522736 |
申请日期 |
2011.01.20 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;SPIEGELMAN BRUCE M.;CHOI JANG HYUN;KAJIMURA SHINGO;BANKS ALEXANDER |
发明人 |
SPIEGELMAN BRUCE M.;CHOI JANG HYUN;KAJIMURA SHINGO;BANKS ALEXANDER |
分类号 |
G01N33/566;A01K67/027;C07K14/72;C07K16/28;C12N15/12;C12Q1/68;C40B30/04 |
主分类号 |
G01N33/566 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|