| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for producing a proline compound (1) or a salt thereof with high yield without using an enzyme. <P>SOLUTION: The method for producing the proline compound or the salt thereof shown by Formula (1), comprises steps A to D. [Step A]: a step of reacting a pyrrolidinone compound with a reducing agent represented by the formula (M<SP POS="POST">s+</SP>)<SB POS="POST">1/s</SB>H<SB POS="POST">4</SB>-mAl<SP POS="POST">-</SP>(OR<SP POS="POST">3</SP>)<SB POS="POST">m</SB>in the presence of a base; [step B]: a step of reacting the pyrrolidinol compound with a cyanating agent; [step C]: a step of hydrolyzing or alcoholizing the cyanopyrrolidine compound; and [step D]: a step of substituting R<SP POS="POST">2</SP>in the protected proline compound by a hydrogen atom. <P>COPYRIGHT: (C)2013,JPO&INPIT |
