发明名称 |
PHARMACOPHORES FOR AMYLOID FIBERS INVOLVED IN ALZHEIMER'S DISEASE |
摘要 |
This invention relates, e.g., to a method for designing or selecting on a computer a candidate small molecule amyloid binder or inhibitor, comprising: a) docking test compounds to the binding site or binding surface determined from the three-dimensional structure of a co-crystal of a protofilament of an amyloid protein bound to a small molecule which is known to bind to the amyloid protein, and (b) selecting test compounds which exhibit an energy below that of the small molecule used to form the co-crystal made in a), as candidate amyloid binders. |
申请公布号 |
WO2013010176(A2) |
申请公布日期 |
2013.01.17 |
申请号 |
WO2012US46945 |
申请日期 |
2012.07.16 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;EISENBERG, DAVID S.;JIANG, LIN;LANDAU, MEYTAL;LIU, CONG |
发明人 |
EISENBERG, DAVID S.;JIANG, LIN;LANDAU, MEYTAL;LIU, CONG |
分类号 |
G01N33/48;A61K48/00;A61K49/00;A61P25/28;G01N33/68;G06F19/00 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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