METHOD FOR THE PURIFICATION OF HBHA

摘要

The present invention concerns a new method for the purification of Heparin Binding Hemagglutinin (HBHA) robust and reproducible at an industrial scale. The purification is made from HBHA-producing microorganisms extracted in presence of a detergent, a solvent or a chaotropic agent, followed by a first elution on ion exchange resins. In a preferred embodiment, the elution on ion exchange resins is followed by a second chromatography on mixed mode sorbents.