| 发明名称 |
POLYSACCHARIDE VACCINE FOR STAPHYLOCOCCAL INFECTION |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a polysaccharide vaccine for staphylococcal infections. <P>SOLUTION: The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG can be isolated from natural sources or synthesized de novo. The invention also relates to the use of dPNAG as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same class of infections. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2013010789(A) |
申请公布日期 |
2013.01.17 |
| 申请号 |
JP20120222333 |
申请日期 |
2012.10.04 |
| 申请人 |
BRIGHAM & WOMEN'S HOSPITAL INC |
发明人 |
PIER GERALD B;MAIRA-LITRAN TOMAS |
| 分类号 |
A61K39/00;A61K31/715;A61K38/00;A61K39/085;A61K39/395;A61K45/00;A61P31/04;C07H3/06;C07K16/12;C08B37/00;C12P19/04;C12P21/00;C12P21/08;G01N33/53 |
主分类号 |
A61K39/00 |
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