发明名称 |
BETA -ADRENERGIC RECEPTOR AGONISTS AND USES THEREOF |
摘要 |
<p>Provided herein are methods for improving function in a retinal cell associated with a diabetic condition and for treating a diabetic retinopathic condition in a subject. The methods comprise contacting the retinal cell or administering to the subject a beta-adrenergic receptor agonist or R-isomer thereof such as have the chemical structural formula: where R1 is (CH2)n(CH3)2 or where n is 1 to 4, R2 is H or H.HX, where X is a halide and R3 is O(CH2)mCH3 at one or more of C2-C6, where m is 0 to 4. Also provided are BAR agonists having the structural where R1 is the (CH2)n-phenyl-R2 substituent and the hydroxy-benzene moiety is 1,2-benzene diol or 1,3-benzene diol.</p> |
申请公布号 |
EP2544677(A2) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20110753709 |
申请日期 |
2011.03.08 |
申请人 |
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION |
发明人 |
STEINLE, JENA, J.;WILLIAMS, KIMBERLY, P.;PAGADALA, JAYAPRAKASH;MILLER, DUANE, D. |
分类号 |
A61K31/138;A61K31/13;A61P27/00;A61P27/02 |
主分类号 |
A61K31/138 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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