发明名称 |
TARGETING APOLIPOPROTEIN B FOR THE REDUCTION OF APOLIPOPROTEIN C-III |
摘要 |
<p>Disclosed herein are compositions and methods for lowering Apolipoprotein C-III (ApoC-III) in a subject in need thereof. Subjects in need of ApoC-III reduction include subjects with elevated ApoC-III levels, subjects with a condition associated with ApoC-III, subjects with diabetes, obese subjects and subjects with cardiovascular disease. Compositions to lower ApoC-III include compounds targeting Apolipoprotein B (ApoB) such as Mipomersen and other antisense compound targeting ApoB.</p> |
申请公布号 |
EP2408796(A4) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20100754009 |
申请日期 |
2010.03.16 |
申请人 |
ISIS PHARMACEUTICALS, INC.;THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
SACKS, FRANK, M.;TRIBBLE, DIANE |
分类号 |
C07H21/04;A61K31/7088;A61P9/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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