METHOD FOR REDUCING SCARRING DURING WOUND HEALING USING ANTISENSE COMPOUNDS DIRECTED TO CTGF
摘要
This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.
申请公布号
EP2334319(A4)
申请公布日期
2013.01.09
申请号
EP20090812035
申请日期
2009.08.26
申请人
EXCALIARD PHARMACEUTICALS, INC.;NORTHWESTERN UNIVERSITY;ISIS PHARMACEUTICALS, INC.
发明人
DEAN, NICOLAS, M.;MUSTOE, THOMAS, A.;SISCO, MARK;KRYGER, ZOL;BENNET, FRANK, C.