| 发明名称 |
METHOD FOR GENOME COMPLEXITY REDUCTION AND POLYMORPHISM DETECTION |
| 摘要 |
<p>The present invention provides methods to produce a reduced representation of a genome for sequencing and DNA polymorphism detection. In particular, the invention provides PCR-based methods, with normalization of the amplified products using a duplex-specific nuclease, in order to reduce over-representation of PCR products. Oligonucleotides for use in the disclosed method are also provided.</p> |
| 申请公布号 |
CA2840493(A1) |
申请公布日期 |
2013.01.03 |
| 申请号 |
CA20122840493 |
申请日期 |
2012.06.27 |
| 申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
KIRST, MATIAS;RIBEIRO DE RESENDE, MARCIO FERNANDO, JR.;NEVES, LEANDRO GOMIDE;DERVINIS, CHRISTOPHER;BALMANT, KELLY MAYRINK |
| 分类号 |
C07H21/00;C07H21/04;C12N15/00;C12P19/34;C12Q1/68;C40B20/00;C40B40/06;C40B50/06 |
主分类号 |
C07H21/00 |
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