发明名称 |
ARIPIPRAZOLE MEDICAMENT FORMULATION AND PREPARATION METHOD THEREFOR |
摘要 |
<p>An aripiprazole medicament formulation and preparation method therefor. The preparation method comprises the following steps: dissolving aripiprazole in an acidic solution having an acidifier so as to obtain a medicament having acidic solution; then, performing a wet granulation on or preparing a suspension with the obtained medicament having acidic solution, an alkalizer, and an excipient so as to obtain the aripiprazole medicament formulation; the excipient comprising an antioxidant. The aripiprazole medicament formulation obtained through the preparation method has a significantly reduced amount of related substances, great solubility, great stability, high bioavailability, reduced individual differences, and enhanced wettability and content uniformity of insoluble medicaments.</p> |
申请公布号 |
WO2013000391(A1) |
申请公布日期 |
2013.01.03 |
申请号 |
WO2012CN77511 |
申请日期 |
2012.06.26 |
申请人 |
SHANGHAI ZHONGXI PHARMACEUTICAL CORPORATION;ZHENG, SIJI;LIU, XIAOYI;FU, LINYONG;TAN, BO;ZHOU, MIN |
发明人 |
ZHENG, SIJI;LIU, XIAOYI;FU, LINYONG;TAN, BO;ZHOU, MIN |
分类号 |
A61K31/496;A61K9/14;A61K9/16;A61K9/20;A61K9/26;A61K47/02;A61K47/04;A61P25/18 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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