发明名称 |
BRAF MUTATIONS CONFERRING RESISTANCE TO BRAF INHIBITORS |
摘要 |
<p>The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.</p> |
申请公布号 |
EP2538943(A1) |
申请公布日期 |
2013.01.02 |
申请号 |
EP20110705795 |
申请日期 |
2011.02.22 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
GARRAWAY, LEVI;EMERY, CAROLINE |
分类号 |
A61K31/4184;C12N9/12 |
主分类号 |
A61K31/4184 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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