发明名称 |
Bispecific EGFR/IGFIR binding molecules |
摘要 |
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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申请公布号 |
US8343501(B2) |
申请公布日期 |
2013.01.01 |
申请号 |
US20090625217 |
申请日期 |
2009.11.24 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;EMANUEL STUART;ENGLE LINDA;CAMPHAUSEN RAY;WRIGHT MARTIN C.;CHAO GINGER;GOTTARDIS MARCO;CARBONI JOAN |
发明人 |
EMANUEL STUART;ENGLE LINDA;CAMPHAUSEN RAY;WRIGHT MARTIN C.;CHAO GINGER;GOTTARDIS MARCO;CARBONI JOAN |
分类号 |
A61K38/17;A61K38/39;A61K47/48;C07K14/435;C07K14/71 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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