发明名称 |
SYSTEM AND METHOD FOR OCULAR IONTOPHORESIS WITH BUFFERING |
摘要 |
Compositions, devices, method of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides and electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least on buffer elementt, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multi-particulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including on or more layers and one or more concentric cylinders. |
申请公布号 |
EP2370155(A4) |
申请公布日期 |
2012.12.26 |
申请号 |
EP20090837075 |
申请日期 |
2009.12.28 |
申请人 |
EYEGATE PHARMACEUTICALS, INC. |
发明人 |
MOSLEMY, PEYMAN;MANZO, MICHAEL;SCHUBERT, WILLIAM;ISOM, WILLIAM;PIERRE, ROY |
分类号 |
A61N1/30;A61N1/04;A61N1/32 |
主分类号 |
A61N1/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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