发明名称 Amines as small molecule inhibitors
摘要 The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. The compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
申请公布号 US8338437(B2) 申请公布日期 2012.12.25
申请号 US20080039141 申请日期 2008.02.28
申请人 WAHHAB AMAL;THERRIEN ERIC;ALLAN MARTIN;MANKU SUKHDEV;METHYLGENE INC. 发明人 WAHHAB AMAL;THERRIEN ERIC;ALLAN MARTIN;MANKU SUKHDEV
分类号 A61K31/4162;C07D487/04 主分类号 A61K31/4162
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