发明名称 |
Methods of screening for antibody light chains |
摘要 |
The present invention relates to methods of screening for commonly shared light chains, in which the method comprises the steps of (a) generating a host secreting the heavy chain of an antibody that binds to a desired antigen; (b) introducing an antibody light chain library into the host of step (a) to generate libraries presenting antibodies composed of the heavy chain and the light chains; (c) selecting a library presenting antibodies that bind specifically to the desired antigen of step (a); (d) introducing the library selected in step (c) into a host secreting the heavy chain of an antibody that binds to a desired antigen different from the antigen of step (a) to generate libraries that display antibodies composed of the heavy chains and light chains; and (e) selecting a library that displays antibodies that bind specifically to the desired antigen of step (d). |
申请公布号 |
US8337841(B2) |
申请公布日期 |
2012.12.25 |
申请号 |
US20050542839 |
申请日期 |
2005.12.13 |
申请人 |
KOJIMA TETSUO;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
KOJIMA TETSUO |
分类号 |
A61K39/395;C07K16/00;C12N1/21;C12N15/74;C12P21/08;C40B40/10 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|