The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.
申请公布号
WO2012167309(A1)
申请公布日期
2012.12.13
申请号
WO2012AU00647
申请日期
2012.06.06
申请人
STARPHARMA PTY LTD;OWEN, DAVID;KELLY, BRIAN DEVLIN;KARELLAS, PETER