发明名称 |
LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER STROMAL-FREE CONDITIONS |
摘要 |
The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion. |
申请公布号 |
US2012315338(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
US201013512827 |
申请日期 |
2010.12.03 |
申请人 |
LI FENG;LU SHI-JIANG;STEM CELL & REGENERATIVE MEDICINE INTERNATIONAL, INC. |
发明人 |
LI FENG;LU SHI-JIANG |
分类号 |
C12N5/078;A61K35/14;A61P7/04;G01N33/566 |
主分类号 |
C12N5/078 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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