Substituted indolo [2,3-a] quinolizines in the treatment of cancer

摘要

The present invention relates to novel substituted indolo [2,3- a ] quinolizines of the general formula (I)
and stereoisomeric forms thereof and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted indolo [2,3- a ] quinolizines together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted indolo [2,3- a ] quinolizines have been identified as useful for the prophylaxis and treatment of cancer by the induction of strong mitotic delays, chromosomal misalignments and mitotic tri- and multipolarization leading to cell cycle stop and apoptosis. Furthermore a synthesis for preparation of the substituted indolo [2,3- a ] quinolizines is disclosed in the present invention.