发明名称 |
Acoustic plethysmograph for measuring pulmonary function |
摘要 |
The present disclosure concerns embodiments of an acoustic plethysmograph for measuring pulmonary function of an animal, such as a mouse. The plethysmograph in exemplary embodiments can measure thoracic tidal volume of an unrestrained animal. The plethysmograph in exemplary embodiments acoustically excites the chamber containing the animal and detects changes in the acoustic pressure in the chamber, which correlate to the thoracic tidal volume of the animal. Unlike the conventional whole-body plethysmograph, this acoustic plethysmograph provides a direct measure of thoracic tidal volume. The plethysmograph also can be configured to measure chamber flow (the flow of air into and out of the chamber). Specific airway resistance of the animal can then be determined from the thoracic tidal volume and plethysmograph flow measurements. |
申请公布号 |
US8328729(B2) |
申请公布日期 |
2012.12.11 |
申请号 |
US20080168829 |
申请日期 |
2008.07.07 |
申请人 |
REYNOLDS JEFFREY S.;FRAZER DAVID G.;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION |
发明人 |
REYNOLDS JEFFREY S.;FRAZER DAVID G. |
分类号 |
A61K0005/000091 |
主分类号 |
A61K0005/000091 |
代理机构 |
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