A spike domain circuit responsive to analog and/or spike domain input signals. Has a hysteresis quantizer for generating a spike domain output signal z(t); a one bit DAC having an input coupled to receive the spike domain output signal z(t) and an output coupled to a current summing node; and a second order filter stage having two inputs, one coupled to receive the spike domain output signal z(t); the other coupled to receive current summed at said current summing node. The second order filter stage has an output coupled to an input of the hysteresis quantizer. The current summing node also receives signals related to the analog and/or spike domain input signals for response. The circuit may serve as a neural node. Many such circuits may be used together to model neurons with complex biological dynamics.