发明名称 |
SUBSITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS |
摘要 |
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula (I) D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group -P-A-P- where A is (Formula I) Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/ and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure. |
申请公布号 |
CA2837481(A1) |
申请公布日期 |
2012.12.06 |
申请号 |
CA20122837481 |
申请日期 |
2012.05.29 |
申请人 |
ACHILLION PHARMACEUTICALS, INC. |
发明人 |
WILES, JASON ALLAN;WANG, QIUPING;HASHIMOTO, AKIHIRO;PAIS, GODWIN;CHEN, DAWEI;WANG, XIANGZHU;GADHACHANDA, VENKAT;PHADKE, AVINASH;DESHPANDE, MILIND |
分类号 |
A61K31/4178;A61K31/395;A61K31/407;A61K31/4184;A61K31/422;A61K31/427;A61K31/439;A61K31/454;A61K31/496;A61P31/00;A61P31/12 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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