发明名称 |
METHOD FOR MANUFACTURING PYRAZOLE DERIVATIVE |
摘要 |
<p>The present invention provides a prolinamide compound useful as a drug or the like and an industrially advantageous method for producing a piperazinyl pyrazole compound that is a production intermediate of the prolinamide compound. Specifically, the invention is a method for producing a compound represented by general formula (1) as represented by the following formula (where the symbols in the formula are the same as defined in the specification) or a salt thereof, wherein a compound represented by general formula (2) is produced, a pyrazole ring being formed via a reaction between a compound represented by general formula (3) and phosphorus pentasulfide; and, once the compound represented by general formula (2) is deprotected, a carboxylate of a compound represented by general formula (6) is produced, the compound obtained by forming a carboxylic acid and a salt.</p> |
申请公布号 |
WO2012165547(A1) |
申请公布日期 |
2012.12.06 |
申请号 |
WO2012JP64075 |
申请日期 |
2012.05.31 |
申请人 |
MITSUBISHI TANABE PHARMA CORPORATION;AKAHOSHI, FUMIHIKO;KIRIHARA, SHINJI |
发明人 |
AKAHOSHI, FUMIHIKO;KIRIHARA, SHINJI |
分类号 |
C07D231/38;A61K31/496;A61P3/10;A61P43/00;C07D417/14 |
主分类号 |
C07D231/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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