| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide protease inhibition. <P>SOLUTION: Proteins (such as proteins having two or more engineered Kunitz domains) including engineered sequences for inhibiting proteases, and uses of such proteins are disclosed. The invention also relates to an isolated protein comprising one or more engineered protease inhibitory sequences having the excessive activity contributing to a disorder selected from the group consisting of rheumatoid arthritis, multiple sclerosis, Crohn's disease, cancer, and chronic obstructive pulmonary disorder, and inhibiting two or more proteases. <P>COPYRIGHT: (C)2013,JPO&INPIT |
