| 摘要 |
Disclosed is a compound of formula (XLVI). Examples of compounds of formula (I) are: 5-(3-(2,6-Dimethylbenzyloxy)-4-methoxybenzyl)-1H-tetrazole; 5-(3-(2,6-Dimethylbenzyloxy)phenethyl)-1H-tetrazole; and 5-(3-(2,6-Dimethylbenzyloxy)-4-methylbenzyl)-1H-tetrazole. The compounds are useful for reducing uric acid levels. The uric acid-lowering effects of the compounds disclosed are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumour-lysis syndrome, cognitive impairment, early-onset essential hypertension, and Plasmodium falciparum-induced inflammation. Also disclosed are pharmaceutical compositions comprising a compound of formula (XLVI). |
