METHODS OF USE FOR CYCLOPAMINE ANALOGS

摘要

Disclosed is the use of a cyclopamine compound of formula (1) or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treatment of a hyperproliferative disorder. The compounds are useful in antagonising the hedgehog pathway. The hyperproliferative can be cancer, in particular a cancer of the pulmonary system, a cancer of the gastrointestinal tract, a skin cancer, a genitourinary cancer, a lung cancer, a medulloblastoma, a basal cell carcinoma, a prostate cancer, an esophageal cancer, a hepatocellular cancer, a gastric cancer, a gastrointestinal stromal tumor (GIST), a colon cancer, a colorectal cancer, an ovarian cancer, a melanoma, head and neck cancer, polycythemia Vera, essential thrombocythemia, a soft-tissue sarcoma, fibrosarcoma, myxosarcoma, liposarcoma, a chondrosarcoma, an osteogenic sarcoma, a chordoma, an angiosarcoma, an endotheliosarcoma, a lymphangiosarcoma, a lymphangioendotheliosarcoma, a synovioma, a leiomyosarcoma, a bladder carcinoma, a squamous cell carcinoma, a hepatoma, a bile duct carcinoma, a neuroendocrine cancer, or a carcinoid tumour.