| 摘要 |
Disclosed are piperidine compounds that have a phenyl ring fused with a diaza heterocyclic ring of formula (II) wherein the substituent Q is naphthalene, and the variables are as defined in the specification. Also disclosed is a composition comprising a compound of formula (II), an in vitro method of modulating ORL-1 receptor function in a cell, the use of a compound of formula (II) in the manufacture of a medicament for treating pain, a memory disorder, obesity, constipation, urinary incontinence, anxiety, cough, diarrhoea, high blood pressure, epilepsy, anorexia/cachexia, or drug abuse; a kit comprising an amount of a compound of formula (II) and a method of preparing a composition comprising the steps of combining a compound of formula (II) with a pharmaceutically acceptable carrier or excipient.
|
