发明名称 |
DIALYSIS FERMENTER-BIOREACTOR WITH DIALYSIS DEVICE |
摘要 |
The present disclosure provides systems and methods of using a semipermeable membrane in a dialysis fermenter as a separation layer between a cell-containing liquid culture medium and a non-cell-containing dialysis medium. In some embodiments, the semipermeable membrane may have a molecular cut-off of 15 kDa to 50 kDa. The instant disclosure also provides a dialysis fermenter with compartments for cell-containing culture medium, non-cell-containing nutrient solution as well as an exchange unit having a semipermeable membrane, wherein mass transfer takes place between the culture medium and the dialysis medium by means of diffusion and/or ultrafiltration. Methods for culturing cells are also disclosed.
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申请公布号 |
US2012301923(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
US201213480446 |
申请日期 |
2012.05.24 |
申请人 |
HOFFMANN ARTUR;LECHNER MAX;REESE CHRISTOPH;ROCHE DIAGNOSTICS OPERATIONS, INC. |
发明人 |
HOFFMANN ARTUR;LECHNER MAX;REESE CHRISTOPH |
分类号 |
C12M1/12;C12N5/07;C12N5/071;C12N5/10;C12N5/12;C12N9/00;C12P21/00 |
主分类号 |
C12M1/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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