发明名称 |
COMPOSITIONS AND METHODS FOR EFFICACIOUS AND SAFE DELIVERY OF SIRNA USING SPECIFIC CHITOSAN-BASED NANOCOMPLEXES |
摘要 |
There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi-inducing nucleic acid to cells both in vitro and in vivo through specific formulations of a non viral delivery system using chitosans. Particularly, the composition contains a nucleic acid and a specific chitosan that has the following physico-chemical properties: a number-average molecular weight between 5 kDa and 200 kDa, a degree of deacetylation between 80% and 95% and a chitosan amine to nucleic acid phosphate ratio below 20. |
申请公布号 |
CA2835147(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
CA20122835147 |
申请日期 |
2012.05.24 |
申请人 |
POLYVALOR S.E.C. |
发明人 |
MERZOUKI, ABDERRAZZAK;BUSCHMANN, MICHAEL D. |
分类号 |
A61K47/36;A61K31/713;A61P3/10;A61P9/10;A61P35/00 |
主分类号 |
A61K47/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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