发明名称 |
TET2 AS A NEW DIAGNOSTIC AND PRONOSTIC MARKER IN HEMATOPOIETIC NEOPLASMS |
摘要 |
The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO:2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour. |
申请公布号 |
US2012302517(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
US201213426040 |
申请日期 |
2012.03.21 |
申请人 |
VIGUIE FRANCK;BERNARD OLIVIER;FONTENAY MICHAELA;BASTARD CHRISTIAN;DELHOMMEAU FRANCOIS;VAINCHENKER WILLIAM;ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS;CENTRE HENRI BECQUEREL;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE PARIS-SUD 11;UNIVERSITE PARIS DESCARTES;UNIVERSITE PIERRE ET MARIE CURIE;INSTITUT GUSTAVE-ROUSSY |
发明人 |
VIGUIE FRANCK;BERNARD OLIVIER;FONTENAY MICHAELA;BASTARD CHRISTIAN;DELHOMMEAU FRANCOIS;VAINCHENKER WILLIAM |
分类号 |
C12Q1/68;A61K31/706 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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