BLOCKAGE OF PAI-1 IN DIABETIC CD34+ STEM CELLS CORRECTS CELLULAR DYSFUNCTION
摘要
Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which PAI-1 expression and/or activity has been transiently blocked. Other methods involve the administration of a PAI-1 blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion. Alternatively, a PAI-1 blocking agent and treated cells are co-administered to a subject in need thereof.
申请公布号
WO2012129513(A3)
申请公布日期
2012.11.29
申请号
WO2012US30387
申请日期
2012.03.23
申请人
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;GRANT, MARIA;BARTELMEZ, STEPHEN, H.;BETASTEM THERAPEUTICS INC.