摘要 |
<p>The invention relates to hypophosphorous acid derivatives of formula (I) wherein - X is H or OH, - R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising - 0-(CH2)n-COOH; - S-(CH2)n-COOH; -NH-(CH2)n-COOH; - 0-(CH,R') -COOH; -O- (CH2)n-OH; OR', -R' being a C1 -C3 alkyl radical;-OH; --COOH; halogen, particularly -F, - CI, -Br, -I, -CF3; -OCF3; -N02; -CH=CH-COOH; - -(CH2)n-COOH; O - (CH2)n- P03H2; O - (CF2)n- P03H2; O - (CH2)n- S03H; O - (CH2)n- CONHOH; O - (CH2)n-tetrazol; O - (CH2)n-hydroxyisoxazol - n = 1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.</p> |
申请人 |
UNIVERSITE PARIS DESCARTES;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE D'AUVERGNE;ACHER, FRANCINE;PIN, JEAN-PHILIPPE;GOUDET, CYRIL;ESCHALIER, ALAIN;BUSSEROLLES, JEROME;RIGAULT, DELPHINE;LEMASSON, ISABELLE;CESARINI, SARA;COMMARE, BRUNO |
发明人 |
ACHER, FRANCINE;PIN, JEAN-PHILIPPE;GOUDET, CYRIL;ESCHALIER, ALAIN;BUSSEROLLES, JEROME;RIGAULT, DELPHINE;LEMASSON, ISABELLE;CESARINI, SARA;COMMARE, BRUNO |