摘要 |
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds. |
申请人 |
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) |
发明人 |
PASTOR FERNANDEZ, JOAQUIN;ALVAREZ ESCOBAR, ROSA MARIA;RIESCO FAGUNDO, ROSARIO CONCEPCION;GARCIA GARCIA, ANA BELEN;RODRIGUEZ HERGUETA, ANTONIO;MARTIN HERNANDO, JOSE IGNACIO;BLANCO APARICIO, CARMEN;CEBRIAN MUNOZ, DAVID ALVARO |