DIASTEREOSELECTIVE SYNTHESIS PROCESS FOR THE PREPARATION OF IMIDAZOLE COMPOUNDS

摘要

A diastereoselective synthesis process for the preparation of an enantiomer of 6-~[amino(4-chlorophenyl)(1-methyl-1 H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)- 1-~methyl-2(1H)-quinolinone which comprises the conversion of (.plusmn.)-6-[chloro(4~-chlomphenyl)(I-methyl-lH-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl~2(IH)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C1-6alkyloxy or naphtalenyl substituted once or twice with Cl-6alkyloxy.