发明名称 |
Solid pharmaceutical dosage form |
摘要 |
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
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申请公布号 |
US8309613(B2) |
申请公布日期 |
2012.11.13 |
申请号 |
US20100880781 |
申请日期 |
2010.09.13 |
申请人 |
ROSENBERG JOERG;REINHOLD ULRICH;LIEPOLD BERND;BERNDL GUNTHER;BREITENBACH JOERG;ALANI LAMAN;GHOSH SOUMOJEET;ABBVIE INC. |
发明人 |
ROSENBERG JOERG;REINHOLD ULRICH;LIEPOLD BERND;BERNDL GUNTHER;BREITENBACH JOERG;ALANI LAMAN;GHOSH SOUMOJEET |
分类号 |
A61K8/72;A61K9/16;A61K9/20;A61K9/48;A61K31/425;A61K31/427;A61K31/513 |
主分类号 |
A61K8/72 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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