发明名称 |
MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO |
摘要 |
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. |
申请公布号 |
US2012283258(A1) |
申请公布日期 |
2012.11.08 |
申请号 |
US201213421899 |
申请日期 |
2012.03.16 |
申请人 |
GUICHERIT OIVIN M.;BOYD EDWARD ANDREW;BOYD JUDITH;BRUNTON SHIRLEY ANN;PRICE STEPHEN;STIBBARD JOHN HARRY ALEXANDER;MACKINNON COLIN H.;CURIS, INC.;GENENTECH, INC. |
发明人 |
GUICHERIT OIVIN M.;BOYD EDWARD ANDREW;BOYD JUDITH;BRUNTON SHIRLEY ANN;PRICE STEPHEN;STIBBARD JOHN HARRY ALEXANDER;MACKINNON COLIN H. |
分类号 |
A61K31/4439;A61K31/444;A61K31/4545;A61K31/5377;A61P9/00;A61P27/02;A61P27/06;A61P29/00;A61P35/00;A61P35/04;A61P37/06 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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