发明名称 |
Multicomponent assemblies having enhanced binding properties for diagnosis and therapy |
摘要 |
An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule. |
申请公布号 |
US8303932(B2) |
申请公布日期 |
2012.11.06 |
申请号 |
US20100834463 |
申请日期 |
2010.07.12 |
申请人 |
CANTRELL GARY L.;BURLEIGH B. DANIEL;MALLINCKRODT LLC |
发明人 |
CANTRELL GARY L.;BURLEIGH B. DANIEL |
分类号 |
A61J3/07;A61K51/00;A61K31/42;A61K31/426;A61K31/505;A61K31/513;A61K31/7072;A61K47/10;A61K47/14;A61K47/18;A61K47/22;A61K47/26;A61K47/32;A61K47/42;A61K47/48;A61K49/00;A61K49/22;A61M36/14;A61P1/16;A61P7/02;A61P35/00 |
主分类号 |
A61J3/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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