发明名称 |
MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION |
摘要 |
Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof. |
申请公布号 |
CA2834232(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
CA20122834232 |
申请日期 |
2012.04.27 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
MULLICK, ADAM;CROOKE, ROSANNE M.;GRAHAM, MARK J.;DOBIE, KENNETH W.;BELL, THOMAS A.;LEE, RICHARD |
分类号 |
A61K31/7088;A61K31/7115;A61K31/712;A61K31/7125;A61P3/06 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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