发明名称 |
COMPOSITIONS AND METHOD FOR TREATING AUTOIMMUNE DISEASES |
摘要 |
The invention provides methods and compositions for treating various autoimmune diseases (such as systemic lupus erythematousu) with an interferon inhibitor ( such as an anti-intereron-alpha monoclonal antibody). More specifically, the invention provides a method of diagnosing, monitoring and adjusting the treatment of such a patient by way of an interferon signature metric (interferon response gene measurement value), a certain anti-dsDNA antibody titre or being ENA-(leverls of extractable nuclear antigens lower than a healthy level). Furthermore, the invention provides articles of manufacture associated with such a diagnosis. |
申请公布号 |
CA2834203(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
CA20122834203 |
申请日期 |
2012.04.26 |
申请人 |
GENENTECH, INC. |
发明人 |
DRAPPA, JORN;MORIMOTO, ALYSSA M.;MCBRIDE, JACQUELINE;BOISMENU, RICHARD;MACIUCA, ROMEO;KENNEDY, WILLIAM D.;TOWNSEND, MICHAEL J. |
分类号 |
A61K39/395;A61P37/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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