发明名称 ETHYNYL COMPOUNDS
摘要 The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3′, R4, R4′, R5, R6, R6′, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
申请公布号 US2012277213(A1) 申请公布日期 2012.11.01
申请号 US201213452973 申请日期 2012.04.23
申请人 JAESCHKE GEORG;JOLIDON SYNESE;LINDEMANN LOTHAR;STADLER HEINZ;VIEIRA ERIC 发明人 JAESCHKE GEORG;JOLIDON SYNESE;LINDEMANN LOTHAR;STADLER HEINZ;VIEIRA ERIC
分类号 A61K31/4439;A61K31/444;A61K31/501;A61K31/506;A61K31/55;A61P25/00;C07D401/04;C07D401/14;C07D403/04 主分类号 A61K31/4439
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