ANTI-CD3 ANTIBODY AND METHOD OF USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide an isolated fully human monoclonal CD3 antibody or fragment thereof.

SOLUTION: The antibody or fragment thereof has the following characteristics that it: a. binds to CD3 positive (CD3+) cells but not CD3 negative (CD3-) cells; b. modulates the cell surface expression level or activity of CD3; and c. decreases the cell surface expression level or activity of the T cell receptor. In one aspect, the antibody inhibits binding of the murine anti-human OKT3 monoclonal antibody to a T-lymphocyte. In another aspect, the antibody binds an epitope that wholly or partially includes the amino acid sequence EMGGITQTPYKVSISGT (SEQ ID NO: 67).

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